Synthesis and biological activity of 2-lactonyl penems.
نویسندگان
چکیده
A series of potent antibacterial agents have been prepared. These agents are penems carrying a lactone ring in the C-2 position. Excellent activity against Gram-positive and Gram-negative organisms--except Pseudomonas aeruginosa--was found.
منابع مشابه
The penems, a new class of beta-lactam antibiotics. 7. Synthesis and antimicrobial activity of 2-heterocyclylmercaptoalkyl derivatives.
2-Heterocyclylmercaptoalkyl penems were synthesized and their in vitro potency was established. The compounds exhibit moderate to strong antibacterial activity against various Gram-positive and Gram-negative bacteria. Their antimicrobial activity is related to the nature of the heterocycle, the length of the hydrocarbon spacer between the 2-position of the penem nucleus and the mercapto group, ...
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The synthesis and in vitro antimicrobial activity of a new penem antibiotic, sodium (5R,6S)-2-(2-fluoroethylthio)-6-[(1R)-1-hydroxyethyl]penem-3-ca rbo xylate (1), are reported. The MIC values of 1 are compared with those of some related 2-haloalkylthio penems prepared in this work, and also Sch 29482 and thienamycin.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 41 6 شماره
صفحات -
تاریخ انتشار 1988